Benefits of using heterologous polyclonal antibodies and potential applications to new and undertreated infectious pathogens
Identifieur interne : 001360 ( Main/Exploration ); précédent : 001359; suivant : 001361Benefits of using heterologous polyclonal antibodies and potential applications to new and undertreated infectious pathogens
Auteurs : Rashmi Dixit [Australie] ; Jenny Herz [Australie] ; Richard Dalton [Royaume-Uni] ; Robert Booy [Australie]Source :
- Vaccine [ 0264-410X ] ; 2016.
Descripteurs français
- KwdFr :
- Anaphylaxie (), Animaux, Anticorps (), Anticorps (usage thérapeutique), Antitoxines (usage thérapeutique), Essais cliniques comme sujet, Histoire du 19ème siècle, Histoire du 20ème siècle, Histoire du 21ème siècle, Humains, Immunisation passive (histoire), Maladies transmissibles (), Prophylaxie après exposition, Sérums antivenimeux (usage thérapeutique).
- MESH :
- histoire : Immunisation passive.
- usage thérapeutique : Anticorps, Antitoxines, Sérums antivenimeux.
- Anaphylaxie, Animaux, Anticorps, Essais cliniques comme sujet, Histoire du 19ème siècle, Histoire du 20ème siècle, Histoire du 21ème siècle, Humains, Maladies transmissibles, Prophylaxie après exposition.
English descriptors
- KwdEn :
- Anaphylaxis (prevention & control), Animals, Antibodies (chemistry), Antibodies (therapeutic use), Antitoxins (therapeutic use), Antivenins (therapeutic use), Clinical Trials as Topic, Communicable Diseases (therapy), History, 19th Century, History, 20th Century, History, 21st Century, Humans, Immunization, Passive (history), Post-Exposure Prophylaxis.
- MESH :
- chemical , chemistry : Antibodies.
- history : Immunization, Passive.
- prevention & control : Anaphylaxis.
- chemical , therapeutic use : Antibodies, Antitoxins, Antivenins.
- therapy : Communicable Diseases.
- Animals, Clinical Trials as Topic, History, 19th Century, History, 20th Century, History, 21st Century, Humans, Post-Exposure Prophylaxis.
Abstract
This review examines their development of heterologous polyclonal antibodies and their potential application future applications. Modern processing techniques have dramatically reduced anaphylaxis and serum hypersensitivity adverse reactions. Studies of rabies antitoxin and snake, scorpion and spider antivenin have demonstrated a high safety and efficacy profile. Heterologous polyclonal antibodies have potential against various emerging infections and longstanding, neglected tropical diseases. Preclinical & phase 1 studies against avian influenza are promising.
Url:
DOI: 10.1016/j.vaccine.2016.01.016
PubMed: 26802604
PubMed Central: 7131169
Affiliations:
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pathogens</title><author><name sortKey="Dixit, Rashmi" sort="Dixit, Rashmi" uniqKey="Dixit R" first="Rashmi" last="Dixit">Rashmi Dixit</name><affiliation wicri:level="3"><nlm:aff id="aff0005">The Children's Hospital, Westmead, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The Children's Hospital, Westmead, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Herz, Jenny" sort="Herz, Jenny" uniqKey="Herz J" first="Jenny" last="Herz">Jenny Herz</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Biointelect, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Biointelect, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Dalton, Richard" sort="Dalton, Richard" uniqKey="Dalton R" first="Richard" last="Dalton">Richard Dalton</name><affiliation wicri:level="1"><nlm:aff id="aff0015">University of Southampton, Southampton, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Booy, Robert" sort="Booy, Robert" uniqKey="Booy R" first="Robert" last="Booy">Robert Booy</name><affiliation wicri:level="3"><nlm:aff id="aff0005">The Children's Hospital, Westmead, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The Children's Hospital, Westmead, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anaphylaxis (prevention & control)</term><term>Animals</term><term>Antibodies (chemistry)</term><term>Antibodies (therapeutic use)</term><term>Antitoxins (therapeutic use)</term><term>Antivenins (therapeutic use)</term><term>Clinical Trials as Topic</term><term>Communicable Diseases (therapy)</term><term>History, 19th Century</term><term>History, 20th Century</term><term>History, 21st Century</term><term>Humans</term><term>Immunization, Passive (history)</term><term>Post-Exposure Prophylaxis</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anaphylaxie ()</term><term>Animaux</term><term>Anticorps ()</term><term>Anticorps (usage thérapeutique)</term><term>Antitoxines (usage thérapeutique)</term><term>Essais cliniques comme sujet</term><term>Histoire du 19ème siècle</term><term>Histoire du 20ème siècle</term><term>Histoire du 21ème siècle</term><term>Humains</term><term>Immunisation passive (histoire)</term><term>Maladies transmissibles ()</term><term>Prophylaxie après exposition</term><term>Sérums antivenimeux (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antibodies</term></keywords><keywords scheme="MESH" qualifier="histoire" xml:lang="fr"><term>Immunisation passive</term></keywords><keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Immunization, Passive</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Anaphylaxis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies</term><term>Antitoxins</term><term>Antivenins</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Communicable Diseases</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps</term><term>Antitoxines</term><term>Sérums antivenimeux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Clinical Trials as Topic</term><term>History, 19th Century</term><term>History, 20th Century</term><term>History, 21st Century</term><term>Humans</term><term>Post-Exposure Prophylaxis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Anaphylaxie</term><term>Animaux</term><term>Anticorps</term><term>Essais cliniques comme sujet</term><term>Histoire du 19ème siècle</term><term>Histoire du 20ème siècle</term><term>Histoire du 21ème siècle</term><term>Humains</term><term>Maladies transmissibles</term><term>Prophylaxie après exposition</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par1010">This review examines their development of heterologous polyclonal antibodies and their potential application future applications.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par2010">Modern processing techniques have dramatically reduced anaphylaxis and serum hypersensitivity adverse reactions.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par3010">Studies of rabies antitoxin and snake, scorpion and spider antivenin have demonstrated a high safety and efficacy profile.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par4010">Heterologous polyclonal antibodies have potential against various emerging infections and longstanding, neglected tropical diseases.</p></list-item><list-item id="lsti0025"><label>•</label><p id="par5010">Preclinical & phase 1 studies against avian influenza are promising.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Von Behring, E" uniqKey="Von Behring E">E. 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Pacal</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Royaume-Uni</li></country><region><li>Nouvelle-Galles du Sud</li></region><settlement><li>Sydney</li></settlement></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Dixit, Rashmi" sort="Dixit, Rashmi" uniqKey="Dixit R" first="Rashmi" last="Dixit">Rashmi Dixit</name></region><name sortKey="Booy, Robert" sort="Booy, Robert" uniqKey="Booy R" first="Robert" last="Booy">Robert Booy</name><name sortKey="Herz, Jenny" sort="Herz, Jenny" uniqKey="Herz J" first="Jenny" last="Herz">Jenny Herz</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Dalton, Richard" sort="Dalton, Richard" uniqKey="Dalton R" first="Richard" last="Dalton">Richard Dalton</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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